In 1921, the Slough Urban District Council took control of the fire brigade, and in 1948 this passed to Buckinghamshire County Council.

In October 1956, the fire brigade in Slough moved to a new station in Tuns Lane, which is still in use today. It was designed by Frederick Pooley, the county architect, and was a major step forward, with direct links to 54 of Slough's largest firms - 18 of them with automatic alarm systems. The location also made the Trading Estate more accessible, and the traffic lights could be controlled from the station to gain immediate access to the Bath Road. In 2005, this was the busiest station in Berkshire.

The original station, in Mackenzie Street, was demolished in 1967, seventy years after it was built. During demolition, a time capsule was found underneath the building, which contained photographs of the original firemen, newspapers from the time, and two bottles of Elliman's Embrocation.

Over the years, Slough's fire brigade has fought several major fires - the first of note was the fire that destroyed Botham's Hotel in 1882. In 1933 there was a fire in Stoke Common which they fought for 23 hours, but even that was eclipsed in 1964, when they spent 32 hours fighting a fire in a timber yard in Langley.

The Slough brigade was also involved in fighting fires at Eton College in 1965, the Trading Estate in 1969, and the Windsor Castle fire in 1992.

In 1963, a sub-station opened in London Road, Langley, and fire-fighters from this station have also taken part in several notable incidents, including 1968's Boeing crash at Heathrow, and the air crash in Staines in 1972, as well as also being involved in fighting the Windsor Castle fire.

In 2002, Slough's fire-fighters became world champions, winning the International World Extrication Title in the USA. This involved rescuing victims of a mock car crash.